Answer: DESPOTS

Despots refer to oppressive rulers or leaders who exercise absolute power and authority without any accountability or regard for the well-being and interests of their people. In the context of the clue "Ones unlikely to rule in your favor," it suggests that despots are highly unlikely to govern in a manner that benefits or supports individuals or the public.

Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Ones unlikely to rule in your favor. Explanations are generated by AI and may be inaccurate.