Answer: DRNO

"Dr. No" is a spy film released in 1962 and is the first installment in the James Bond film series. It features the fictional British secret agent, James Bond, also known as Agent 007. The film is based on the novel of the same name by Ian Fleming. In "Dr. No," Bond is sent on a mission to investigate the disappearance of a fellow agent and uncovers a plot involving a villainous scientist named Dr. Julius No. The film marked the debut of actor Sean Connery in the role of James Bond and introduced many of the iconic elements associated with the Bond franchise.

Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Bond villain with an island lair. Explanations are generated by AI and may be inaccurate.