The Inca were a pre-Columbian civilization in South America. They were known for creating the Inca Empire, which functioned without the use of money. The Inca Empire was located in the Andes Mountains and was one of the largest empires in pre-Columbian America.
Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Largest empire in pre-Columbian America. Explanations are generated by AI and may be inaccurate.