Answer: INDIANTERRITORY

Indian Territory refers to an area in the United States that was designated for the relocation of Native American tribes during the 19th century. It was located in present-day Oklahoma and parts of Kansas and Nebraska. The term "Indian Territory" appeared on old U.S. maps to identify this specific region.

Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Designation on old U.S. maps. Explanations are generated by AI and may be inaccurate.