Answer: LISP

Lisp is a speech disorder that affects the pronunciation of certain sounds, particularly the "s" and "z" sounds. People with a lisp might have difficulty producing these sounds correctly, often resulting in a distortion or substitution of the sound. A lisp is a challenge for speech pathologists, who work with individuals to improve their speech patterns and correct any difficulties in articulation.

Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Speech therapy subject. Explanations are generated by AI and may be inaccurate.