Lyme refers to Lyme, a town located in Southeast Connecticut. It is also commonly known as Lyme Disease, which is a tick-borne illness caused by the bacterium Borrelia burgdorferi. It can cause various symptoms, including fever, fatigue, headache, muscle and joint aches, and sometimes a characteristic skin rash.
Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Eponymous town in SE Connecticut. Explanations are generated by AI and may be inaccurate.