Milo refers to the character "Milo" from a 1989 film called "Milo and Otis." In the film, Otis is a dog and Milo is his feline (cat) friend.
Note: The provided meaning of the answer is for the latest New York Times crossword puzzle clue: Otis's feline friend in a 1989 film. Explanations are generated by AI and may be inaccurate.